Villani also scored the first boundary of the season with a reverse sweep from the fifth ball of the first over.
Bolton was one of four high-profile recruits in the Sixers’ line-up after retiring from the Women’s National Cricket League, where she played with Western Australia for 15 years.
The others were Indian internationals Shafali Verma, the dashing teenage opening batter, and left-arm spinner Radha Yadav, along with former Melbourne Renegades seamer Maitlan Brown.
Verma made her first impact in the field when she threw the stumps down from mid-wicket to run out young all-rounder Annabelle Sutherland, who scored 14 from 19 balls after being promoted to open the batting. The brilliant fielding ended an opening partnership of 49 in 5.5 overs dominated by Villani.
Sutherland later had her revenge, bowling Verma for just eight from 10 balls when an ambitious slog went wrong. Healy dominated their opening partnership of 40.
Sixers captain Ellyse Perry introduced herself as the fifth bowler and struggled in the slippery conditions, conceding consecutive fours to Villani.
She hit the first ball of Perry’s next over to long-on for six and took 17 from the first five balls in an over which cost 18 runs, leaving Perry with the figures of 0-27 from two overs.
Play was delayed by an hour and a half because of rain which threatened to wash the match out. Healy said it was the wettest ground she ever played on, describing it as “treacherous”.
The first 20 matches of the WBBL are being played in Hobart because COVID restrictions and border closures made a traditional home-and-away tournament impossible.